Defthand's Dissolvent ★★★

Nothing in this list is craftable in turn, so one Defthand's Dissolvent is a single step: 5 units of material drawn from 3 base items, plus 4 crystals.

That bill outweighs 4,201 of the 13,602 recipes tracked here and 826 of the 1,591 Alchemist ones, and 9,374 recipes nest deeper.

1 of the 3 raw materials come out of the ground, and one of them is time-gated: Tender Dill (0:00, 12:00). The widest gap between consecutive opening times is 12 Eorzean hours, about 35 real-world minutes.

Defthand's Dissolvent is itself consumed by 16 further recipes, spanning four of the eight crafting classes.